Triadic IBD coefficients and applications to estimating pairwise relatedness
نویسندگان
چکیده
منابع مشابه
Estimating Seven Coefficients of Pairwise Relatedness Using Population-Genomic Data.
Population structure can be described by genotypic-correlation coefficients between groups of individuals, the most basic of which are the pairwise relatedness coefficients between any two individuals. There are nine pairwise relatedness coefficients in the most general model, and we show that these can be reduced to seven coefficients for biallelic loci. Although all nine coefficients can be e...
متن کاملEstimation of pairwise relatedness with molecular markers.
Applications of quantitative genetics and conservation genetics often require measures of pairwise relationships between individuals, which, in the absence of known pedigree structure, can be estimated only by use of molecular markers. Here we introduce methods for the joint estimation of the two-gene and four-gene coefficients of relationship from data on codominant molecular markers in random...
متن کاملOn inferring and interpreting genetic population structure - applications to conservation, and the estimation of pairwise genetic relatedness
The presence of population structure is ubiquitous in most wild populations of species. Detecting genetic population structure and understanding its consequences for the evolutionary trajectories of species has shaped a lot of our understanding of the process of evolution. This delineation of subdivision within a population plays an important role in several allied fields, including conservatio...
متن کاملFast pairwise IBD association testing in genome-wide association studies
MOTIVATION Recently, investigators have proposed state-of-the-art Identity-by-descent (IBD) mapping methods to detect IBD segments between purportedly unrelated individuals. The IBD information can then be used for association testing in genetic association studies. One approach for this IBD association testing strategy is to test for excessive IBD between pairs of cases ('pairwise method'). Ho...
متن کاملEstimating the distribution of selection coefficients from phylogenetic data with applications to mitochondrial and viral DNA.
The distribution of selection coefficients of new mutations is of key interest in population genetics. In this paper we explore how codon-based likelihood models can be used to estimate the distribution of selection coefficients of new amino acid replacement mutations from phylogenetic data. To obtain such estimates we assume that all mutations at the same site have the same selection coefficie...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetical Research
سال: 2007
ISSN: 0016-6723,1469-5073
DOI: 10.1017/s0016672307008798